Fish Oil Could Prevent AAA Induced by Hypoperfusion


Abdominal aortic aneurysm (AAA) is a serious vascular disease.  It's an aneurysm (swelling) of the aorta (main blood-vessel leading away from our heart muscle, down through your belly through to the rest of the body).  AAA is histologically epitomized by:

  • Oxidative stress
  • Chronic (long lasting) inflammation
  • Extracellular matrix degradation in the vascular wall

Preventative methods for hypoperfusion (shock)-induced AAA are still unknown. Scientists evaluated the effect that fish oil (FO) had on AAA development. In this trial they used a hypoperfusion-induced AAA animal model. The animals were divided into two groups: FO administered group and control group. The findings were as follows: dilation of the abdominal aorta in the FO-administration group was smaller than it was in the control group. Collagen destruction along with oxidative-stress was suppressed in the FO-administration group. These results go some way to suggested that FO might help to prevent the development of abdominal aortic aneurysm induced by hypoperfusion.

Resource

The preventive effect of fish oil on abdominal aortic aneurysm development.

Kugo H, Zaima N, Mouri Y, Tanaka H, Yanagimoto K, Urano T, Unno N, Moriyama T.

http://www.ncbi.nlm.nih.gov/pubmed/27022887

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